The research group Evolution of Meiosis (Marques lab), belonging to the Department of Chromosome Biology at the MPIPZ - Cologne, is interested in the study of meiotic adaptations and recombination mechanisms taking place in holocentric plants. Here, we address these questions using as model plant species from the genus Rhynchospora, which have species with both chiasmatic and achiasmatic inverted meiosis.
Holocentric chromosomes differ from monocentric chromosomes by the absence of a primary constriction (known as centromere) due to a diffuse kinetic activity along the entire chromosome arms. This specialized type of chromosome structure is found in several lineages of plants and animals, with multiple independent origins. Recent studies have shown that, in fact, holocentric chromosomes are composed by multiple centromere-like domains distributed genome-wide (holocentromeres). Position and distribution of chromosome compartments (i.e. topological association domains) and meiotic recombination are strongly influenced by the presence of centromeres. In principle, holocentric organisms show chromosomal adaptations related to chromosome segregation and functioning, such as inverted meiosis. However, lack of detailed genomic studies on holocentric plants hampers the elucidation of the impact of such chromosome structure in a comprehensive evolutionary and functional perspective. Understanding how the genome architecture and how recombination are regulated in holocentric genomes will potentially unveil new molecular mechanisms of great interest for the scientific community.
In the framework of this research project, which aims to elucidate the genome organization and architecture, meiotic adaptations and recombination frequencies in the holocentric plants of Rhynchospora, we are looking for a highly motivated PhD candidate.
Please find below the description of the available position:
● You are about to finish* or own a Master degree in Bioinformatics or related field
● You have a background in genomics, recombination analysis, meiosis, evolution
● You do have solid English skills, which are a prerequisite for an effective work in our multicultural working environment
The Max-Planck society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.
If you would like to work in a dedicated team, please convince us now by sending us your complete application documents together with your earliest possible date of joining the institute.
Have we sparked your interest ?
Please apply. We are looking forward to getting your complete application documents.